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Aging Mechanisms: Longevity, Metabolism, and Brain Aging - download pdf or read online

By Nozomu Mori, Inhee Mook-Jung

This ebook brings jointly the main up to date details on fresh study result of prime laboratories on getting older technology in East Asia, really in Japan, Korea, and Hong Kong. beginning with a entire evaluate of varied hypotheses on organic mechanisms of getting older via Dr. Sataro Goto, every one bankruptcy covers extensive facets of the newest findings in aging-related subject matters: centenarian reports and genome research of progeria, metabolic biochemistry and neurobiology, toughness controls in yeast and nematodes, oxidative pressure and calorie restrict, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s ailments, with extra strength healing techniques to those age-related neurodegenerative ailments. additionally incorporated, partly, is a precis and the results of a systematic dialogue discussion board referred to as the Asian getting older middle for sturdiness (AACL) that has been held each year alternating among Japan and Korea over the last decade. This booklet can function an invaluable source for locating acceptable collaborators within the components it covers. the objective readership is made from graduate scholars and researchers at universities, scientific and/or life-science faculties, and biomedical and pharmaceutical institutes.

Why does getting older exist? How can we age? How is each one organism’s lifespan made up our minds? those are primary questions within the box. We should be nonetheless faraway from reaching a whole view of getting older mechanisms, yet this e-book, Aging Mechanisms, deals a very good chance to get to grips with the main up-to-date development within the biomedical examine of getting older in Japan and Korea, the 2 major international locations for human longevity.

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The University of Chicago Press, Chicago Finkel T (2011) Signal transduction by reactive oxygen species. J Cell Biol 194:7–15 Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN (1990) Oxidative damage to DNA during aging: 8-hydroxy-20 -deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci U S A 87:4533–4537 Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML et al (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102: 10604–10609 Gems D, Partridge L (2008) Stress-response hormesis and aging: “that which does not kill us makes us stronger”.

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Physiol Rev 59:527–605 Ciechanover A (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 6:79–87 Comfort A (1964) Ageing. The biology of senescence. Routledge & Kegan Paul Ltd, London Cuervo AM, Dice JF (2000) Age-related decline in chaperone-mediated autophagy. J Biol Chem 275:31505–31513 Cutler RG (1991) Recent progress in testing the longevity determinant and dysdifferentiation hypotheses of aging. Arch Gerontol Geriatr 12:75–98 Cutler RG, Rodriguez H (2003) Critical review of oxidative stress and aging.

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