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Alzheimer's disease and related disorders annual, 2002 - download pdf or read online

By Jeffrey L Cummings, Serge Gauthier

Given the improvement of latest healing suggestions and items, Serge Gauthier and Jeffrey Cummings have compiled a listing of up to date themes so that it will be of curiosity essentially to neurologists concentrating on Alzheimer's ailment, and likewise to psychiatrists and geriatricians. The individuals, all revered of their subspecialties, have written updated, comprehensively referenced chapters which should supply suggestions in addition to stimulate dialogue on the place present therapy is heading.

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Rev Neurosci 2001; 12:311–325. 84. Kondo M, Imahori Y, Mori S et al. Aberrant plasticity in Alzheimer’s disease. Neuroreport 1999; 10: 1481–1484. Alzheimers CH02 36 17/6/02 2:36 pm Page 36 Apoptosis and its role in Alzheimer’s Disease 85. Flood DG, Coleman PD. Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer’s disease. Prog Brain Res 1990; 83:435–443. 86. Buttini M, Orth M, Bellosta S et al. Expression of human apolipoprotein E3 or E4 in the brains of Apoe–/– mice: isoform-specific effects on neurodegeneration.

Mechanochemical mechanism for peptidyl free radical generation by amyloid fibrils. FEBS Lett 1997; 403:230–235. 94. Bruce AJ, Malfroy B, Baudry M. Beta-amyloid toxicity in organ- otypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci USA 1996; 93:2312–2316. 95. Hensley K, Aksenova M, Carney JM et al. Amyloid beta-peptide spin trapping. I: Peptide enzyme toxicity is related to free radical spin trap reactivity. Neuroreport 1995; 6:489–492.

J Biol Chem 1997; 272:17907–17911. Alzheimers CH02 32 17/6/02 2:36 pm Page 32 Apoptosis and its role in Alzheimer’s Disease 12. Howard AD, Kostura MJ, Thornberry N et al. IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha. J Immunol 1991; 147:2964– 2969. 13. Thornberry NA, Bull HG, Calaycay JR et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.

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